Home Renal & Nephrology Renal Replacement Therapy: Haemodialysis

Renal Replacement Therapy: Haemodialysis

๐Ÿ“‹ Key Information Summary

๐Ÿ“‹
  • Haemodialysis (HD) removes uraemic toxins and excess fluid via diffusion and convection across a semipermeable membrane; standard prescription is 4 hours, 3 times weekly in Australia.
  • Australia has ~14,000 patients on maintenance HD (ANZDATA 2023); prevalence is highest among Aboriginal and Torres Strait Islander peoples in remote communities.
  • Arteriovenous fistula (AVF) is the preferred vascular access โ€” "fistula first" policy; target maturation time 6โ€“12 weeks; primary patency superior to grafts and central venous catheters (CVCs).
  • Tunneled CVCs carry 2โ€“3ร— higher bacteraemia risk than AVFs; avoid as long-term access; right internal jugular vein is the preferred insertion site.
  • Adequacy targets: single-pool Kt/V (spKt/V) โ‰ฅ 1.4 per session; URR โ‰ฅ 70%; eKt/V โ‰ฅ 1.2; re-evaluate if targets not met after optimising blood flow and session time.
  • Intradialytic hypotension (IDH) is the most common acute complication (20โ€“30% of sessions); manage with cool dialysate, sodium profiling, midodrine, and accurate dry-weight assessment.
  • Dialyser re-use is NOT standard practice in Australia; single-use high-flux biocompatible membranes (polysulphone, polyethersulphone) are standard.
  • Dialysis disequilibrium syndrome (DDS) risk in new starters โ€” use reduced blood flow rate (150โ€“200 mL/min) and shortened initial sessions; consider hypertonic saline prophylaxis.
  • Hepatitis B: all HD patients must receive vaccination; seroconversion monitored; dedicated machines for HBsAg-positive patients per state guidelines.
  • Anticoagulation: unfractionated heparin (UFH) is standard; citrate regional anticoagulation for patients with bleeding risk; heparin-free dialysis as alternative.
  • PBS: erythropoiesis-stimulating agents (ESAs), phosphate binders, and active vitamin D analogues are Authority Required items; iron (IV ferric carboxymaltose, iron polymaltose) is PBS-listed for CKD patients.
  • Home haemodialysis (HHD) is encouraged where suitable โ€” Australian programmes report equivalent survival with improved quality of life; nocturnal HHD (6โ€“8 hrs, 5โ€“6 nights/week) provides superior solute clearance.

Introduction & Australian Epidemiology

Haemodialysis (HD) is the most widely used renal replacement therapy (RRT) modality worldwide. It employs diffusion and convection across a semipermeable membrane to remove uraemic toxins, correct electrolyte and acidโ€“base disturbances, and ultrafilter excess fluid. In Australia, standard in-centre HD is typically prescribed as 4-hour sessions, 3 times per week, though home haemodialysis (HHD) and extended/nocturnal regimens are increasingly adopted.

According to the Australia and New Zealand Dialysis and Transplant Registry (ANZDATA), approximately 14,000 Australians were receiving maintenance dialysis at the end of 2022, with HD accounting for roughly 75% of all dialysis patients. The crude incidence of treated end-stage kidney disease (ESKD) is approximately 12 per million population per year in the non-Indigenous population, rising to >50 per million in Aboriginal and Torres Strait Islander communities โ€” a disparity driven by the high prevalence of type 2 diabetes, hypertension, and delayed presentation to nephrology services.

Australia operates a mix of public hospital-based, private satellite, and home HD programmes. Medicare and the National Disability Insurance Scheme (NDIS) cover HD costs; the majority of patients receive treatment in publicly funded hospital or satellite units. Home haemodialysis is actively promoted by Kidney Health Australia and the National Aboriginal Community Controlled Health Organisation (NACCHO) as a strategy to improve patient autonomy and reduce the burden of travel, particularly for patients in regional and remote areas.

โš ๏ธ
Cultural safety: Aboriginal and Torres Strait Islander patients may need to relocate for HD access. Support services, patient travel assistance schemes (state/territory funded), and culturally safe care pathways should be arranged early in the planning process.
Renal Replacement Therapy: Haemodialysis clinical infographic โ€” pathophysiology, clinical clues, diagnosis, imaging, and management
Tap or click image to enlarge โ€” Renal Replacement Therapy: Haemodialysis: pathophysiology, clinical clues, diagnosis, imaging, and management.
Renal Replacement Therapy: Haemodialysis infographic, full size

Principles of Haemodialysis

Diffusion

The primary solute removal mechanism. Uraemic toxins (urea, creatinine, potassium, phosphate) move down their concentration gradient from blood to dialysate across the semipermeable membrane. Small molecules (<500 Da) clear rapidly; middle molecules (ฮฒโ‚‚-microglobulin, 11,800 Da) require high-flux membranes and convective clearance.

Convection (Ultrafiltration)

Hydrostatic pressure drives plasma water (and solutes dissolved in it) across the membrane โ€” "solvent drag." Essential for fluid removal and middle-molecule clearance. In haemodiafiltration (HDF), substitution fluid replacement augments convective transport; HDF is increasingly used in Australia with reported survival benefit in large European trials (ESHOL, CONTRAST).

Membrane Characteristics

Feature Low-Flux High-Flux
Ultrafiltration coefficient (Kuf) <10 mL/hr/mmHg >20 mL/hr/mmHg
ฮฒโ‚‚-microglobulin clearance Minimal >20 mL/min
Typical material Cellulose acetate, cuprophane Polysulphone, polyethersulphone, AN69
Biocompatibility Lower Higher
Australian standard use Rarely used Standard of care

Dialysate Composition (Standard Bicarbonate Dialysate)

Component Concentration
Sodium138โ€“140 mmol/L
Potassium2.0 mmol/L (range 1โ€“4)
Calcium1.25โ€“1.75 mmol/L
Magnesium0.5โ€“0.75 mmol/L
Bicarbonate32โ€“40 mmol/L
Glucose5.5 mmol/L (100 mg/dL)

Water Treatment

Dialysis water must meet AS/NZS 4753 and the Australian Commission on Safety and Quality in Health Care (ACSQHC) standards. Reverse osmosis, deionisation, and ultrafiltration are used in series. Bacterial endotoxin must be <0.25 EU/mL (ultrapure) or <0.03 EU/mL (ultrapure for HDF). Water quality is monitored quarterly by pathology services or private water treatment companies accredited under NATA.

Vascular Access (AVF, AVG, CVC)

Vascular access is the lifeline for HD. The Kidney Disease Outcomes Quality Initiative (KDOQI) and the Caring for Australasians on Renal Impairment (CARI) guidelines endorse a "fistula-first" approach. AVFs have the lowest infection rates, best long-term patency, and lowest overall cost.

Preferred
Arteriovenous Fistula (AVF)
Surgical anastomosis of artery to vein (usually radiocephalic at wrist, or brachiocephalic at elbow). Maturation 6โ€“12 weeks. Target: โ‰ฅ600 mL/min blood flow, โ‰ฅ6 mm diameter, <6 mm depth.
Setting: Planned creation โ‰ฅ6 months before anticipated HD start
Alternative
Arteriovenous Graft (AVG)
Synthetic conduit (PTFE, Vectraยฎ) between artery and vein. Can be used 2โ€“4 weeks post-insertion. Higher stenosis and infection rates than AVF; suitable when native vessels are inadequate (elderly, diabetic).
Setting: When native AVF creation fails or is anatomically unsuitable
Bridge / Emergency
Central Venous Catheter (CVC)
Tunneled (e.g., Tesio, Permcath) or non-tunneled. Right internal jugular vein preferred. Associated with higher infection, central venous stenosis, and mortality. Should not be used long-term if avoidable.
Setting: Urgent HD initiation, bridge to maturing AVF/AVG

AVF Planning & Referral Timing

  • Refer to vascular access surgeon when eGFR <20 mL/min/1.73 mยฒ (or <15 mL/min if rapidly declining).
  • Pre-operative vascular mapping by duplex ultrasound โ€” MBS item 55221 (renal dialysis access planning ultrasound).
  • Preserve non-dominant arm veins โ€” avoid venipuncture, IV cannulae, and PICC lines in the non-dominant forearm.
  • Maturation assessment at 4โ€“6 weeks post-creation by clinical exam and ultrasound; promote maturation with squeeze-ball exercises.

AVF Complications

Complication Incidence Management
Primary failure (non-maturation) 20โ€“50% Percutaneous angioplasty (PTA); surgical revision; new access site
Stenosis Common (anastomotic, cephalic arch) Surveillance ultrasound Q3โ€“6 months; PTA if >50% stenosis with clinical signs
Thrombosis 0.5โ€“1.0 per access-year Surgical thrombectomy, pharmacomechanical thrombolysis; MBS item 35302
Aneurysm / pseudoaneurysm Variable Monitor if stable; surgical repair if enlarging, painful, or skin breakdown
Infection (AVF) Rare (<1%) IV antibiotics (flucloxacillin or vancomycin if MRSA risk); surgical drainage if abscess
Infection (CVC) 2.5โ€“5.5 per 1000 catheter-days See CVC-related bacteraemia management below
Steal syndrome 1โ€“8% DRIL procedure (distal revascularisation-interval ligation), banding, or ligation

CVC-Related Bloodstream Infection (CRBSI)

๐Ÿšจ
Suspect CRBSI if rigors, fever >38.0ยฐC, or haemodynamic instability occurring during or within 30 minutes of HD session in a patient with a CVC. Obtain paired blood cultures (one peripheral, one from each CVC lumen) BEFORE antibiotics. Report to state/territory health department if staphylococcal bacteraemia.

Empirical antibiotics: IV vancomycin 25 mg/kg (max 2 g) loading dose + IV gentamicin 2 mg/kg (dose post-HD session, adjusted for residual renal function) pending culture results. If Staphylococcus aureus bacteraemia confirmed: treat for 4โ€“6 weeks; remove CVC if possible; obtain transoesophageal echocardiogram (TOE) to exclude endocarditis. Lock therapy (ethanol or taurolidine) may be used as adjunct but does not replace systemic antibiotics.

AVF/AVG Cannulation Technique

Buttonhole technique (same-site cannulation with blunt needles after track formation) is suitable for home HD patients โ€” reduces pain and complication rates. Rope-ladder technique (alternating sites along the fistula) is standard in-centre. Area puncture should be avoided due to aneurysm risk. Australian nursing training programmes (e.g., Kidney Health Australia Home HD Training) include cannulation competency modules.

Adequacy (Kt/V, URR)

Dialysis adequacy measures ensure sufficient solute removal and are used to guide prescription adjustments. The two most widely used metrics in Australian units are the single-pool Kt/V (spKt/V) and the urea reduction ratio (URR).

Key Definitions

  • Kt/V: K = dialyser clearance (mL/min), t = session duration (min), V = patient's urea distribution volume (mL). Represents the volume of plasma cleared of urea per session, normalised to V. spKt/V calculated by the Daugirdas second-generation equation.
  • URR: (Pre-BUN โˆ’ Post-BUN) / Pre-BUN ร— 100. Simpler to calculate but does not account for ultrafiltration volume.
  • eKt/V (equilibrated): Accounts for urea rebound post-dialysis. Typically 0.2 units lower than spKt/V. Used in some Australian units for extended or nocturnal regimens.

Adequacy Targets (KDOQI / CARI / Australian Practice)

Metric Minimum Target Comment
spKt/V (standard 4-hr session) โ‰ฅ 1.4 per session KDOQI minimum; Australian units target โ‰ฅ1.4
eKt/V (standard 4-hr session) โ‰ฅ 1.2 per session Accounts for rebound; more relevant for thrice-weekly
URR โ‰ฅ 70% Simple surrogate; does not capture ultrafiltration contribution
nPCR / nPNA โ‰ฅ 1.0 g/kg/day Normalised protein catabolic rate โ€” marker of nutritional status

Measurement Protocol

  • Monthly pre- and post-dialysis blood urea nitrogen (BUN) samples โ€” MBS item 66804 (monthly dialysis review).
  • Post-dialysis BUN: draw 10โ€“20 seconds after slowing blood pump to 50โ€“100 mL/min (slow-flow method) to minimise access recirculation artefact.
  • Quarterly: serum bicarbonate (pre-dialysis, target โ‰ฅ22 mmol/L), albumin, calcium, phosphate, PTH, haemoglobin, iron studies.
  • Access recirculation >15% suggests access dysfunction โ€” investigate with duplex ultrasound.

Strategies to Improve Adequacy

1
Increase session time
From 4 hours to 4.5 or 5 hours โ€” most effective single intervention. Extended/nocturnal HD (6โ€“8 hrs) provides superior clearance.
2
Optimise blood flow rate (QB)
Target 300โ€“400 mL/min (AVF); 250โ€“350 mL/min (AVG); 200โ€“300 mL/min (CVC). Ensure access quality allows adequate QB.
3
Increase dialysate flow rate (QD)
Standard 500 mL/min; increasing to 800 mL/min can improve small-molecule clearance by 10โ€“15%.
4
Change dialyser membrane
Use high-efficiency, large-surface-area dialyser (โ‰ฅ1.8 mยฒ) with high KoA for urea.
5
Address recirculation and access dysfunction
Reversal of needle direction, access revision, or PTA for stenosis.

Complications & Management

Acute / Intradialytic Complications

Complication Frequency Key Management
Intradialytic hypotension (IDH) 20โ€“30% of sessions Trendelenburg position; NS 100โ€“200 mL bolus; reduce UF rate; cool dialysate (35.5ยฐC); midodrine 2.5โ€“10 mg PO pre-HD; re-evaluate dry weight
Cramps 5โ€“20% NS bolus; reduce UF rate; quinine sulfate 200โ€“300 mg PO (PBS-listed); stretching; sodium profiling
Nausea / vomiting 5โ€“15% Ondansetron 4 mg IV/PO; assess for IDH, disequilibrium, or dialysate issues
Headache / disequilibrium Common in new starters Reduce QB for first sessions; hypertonic saline (3%) 30โ€“50 mL bolus; mannitol 1 g/kg IV (rarely needed)
Fever / rigors (dialyser reaction) Rare with biocompatible membranes Stop dialysis; blood cultures; empiric antibiotics if sepsis suspected; consider endotoxin in water/dialysate
Anaphylaxis / hypersensitivity <1% Stop dialysis immediately; adrenaline 500 mcg IM; switch membrane type (avoid AN69 if ACE-inhibitor co-prescribed)
Air embolism Rare Clamp lines; Trendelenburg left lateral; 100% Oโ‚‚; aspirate air via CVC if possible; call code blue
Blood leak Rare Machine alarms automatically; stop dialysis; do not return blood; replace dialyser

Chronic / Long-Term Complications

Complication Mechanism / Notes Management
Cardiovascular disease Leading cause of death (40โ€“50%); LVH, accelerated atherosclerosis, arrhythmias BP target <140/90 mmHg (pre-dialysis); statins (PBS-listed atorvastatin); smoking cessation; fluid management; assess for sleep apnoea
CKD-MBD Hyperphosphataemia, secondary hyperparathyroidism, adynamic bone disease Phosphate binders (sevelamer, calcium carbonate โ€” PBS Authority); cinacalcet (PBS Authority Required); active vitamin D (calcitriol, alfacalcidol โ€” PBS General Benefit)
Anaemia EPO deficiency, iron deficiency, inflammation Target Hb 100โ€“115 g/L; darbepoetin alfa (PBS Authority โ€” Aranespยฎ); IV iron (ferric carboxymaltose โ€” Ferinjectยฎ PBS; iron polymaltose โ€” Ferrosigยฎ)
Infection (non-access) Immunodeficiency of uraemia; influenza, pneumococcal, COVID-19 risk Annual influenza vaccine; 23vPPV then 13vPCV (National Immunisation Programme); COVID-19 boosters; HBV vaccination series
Amyloidosis (DRA) ฮฒโ‚‚-microglobulin deposition after >10 years on HD High-flux dialyser or HDF; consider transplant referral; symptomatic management (NSAIDs avoided; paracetamol, joint aspiration)
Depression & fatigue Prevalence 20โ€“30%; underdiagnosed PHQ-9 screening annually; CBT; SSRIs (sertraline preferred โ€” renally safe); peer support; consider exercise programme
Malnutrition Protein-energy wasting; catabolic state Dietitian review (MBS GPMP); protein intake 1.0โ€“1.2 g/kg/day; oral nutritional supplements (PBS-eligible in some cases); pre-dialysis snacks

Anticoagulation During Haemodialysis

๐Ÿ’Š
Unfractionated Heparin (UFH)
Heparin Sodium ยท Various brands ยท Anticoagulant
Adult dose Bolus 1,000โ€“2,000 units IV at start; infusion 500โ€“1,500 units/hr via infusion pump; stop 30โ€“60 min before end of session
Monitoring APTT (not routinely required for standard HD); observe for clotting in dialyser/lines
Bleeding risk Use heparin-free HD (NS flushes Q15โ€“30 min) or citrate regional anticoagulation for high-risk patients
PBS status โœ” PBS General Benefit

Heparin-Free Dialysis Protocol

  • Indicated for: active bleeding, post-operative (within 48โ€“72 hrs), thrombocytopenia, HIT (heparin-induced thrombocytopenia).
  • Flush lines with 100โ€“200 mL NS every 15โ€“30 minutes (saline push method).
  • Consider reduced session time; increase monitoring of transmembrane pressure (TMP) for clotting.
  • For HIT: switch to argatroban (off-label for HD in Australia โ€” requires haematology consultation) or citrate regional anticoagulation.

Investigations

Routine investigations are essential for monitoring HD adequacy, detecting complications, and guiding therapy. The following schedule aligns with CARI/KDOQI guidelines and Australian laboratory practice.

Essential
Monthly BUN (pre- and post-dialysis) + Creatinine
MBS item 66804 โ€” Monthly dialysis review; calculate Kt/V and URR
Essential
Monthly serum bicarbonate (pre-dialysis)
Target โ‰ฅ22 mmol/L; adjust dialysate bicarbonate concentration if acidotic
Essential
Quarterly: calcium, phosphate, PTH, albumin, haemoglobin, iron studies
MBS items 66830 (quarterly review); CKD-MBD monitoring per KDIGO 2017
Available
Parathyroid hormone (PTH intact)
Target 2โ€“9 ร— upper limit of normal; guide cinacalcet/vitamin D therapy
Available
Hepatitis B serology (HBsAg, anti-HBs, anti-HBc)
At HD commencement and annually; anti-HBs >10 IU/L post-vaccination
Available
Hepatitis C antibody + RNA
At baseline and annually; direct-acting antivirals (DAAs) are PBS-listed for CKD patients
Available
HIV serology
At baseline; repeat as clinically indicated; confidential; universal precautions for all patients regardless
Available
Duplex ultrasound of vascular access
MBS item 55221; Q3โ€“6 months for surveillance or if clinical concern (high/low pressures, low Kt/V)
Specialist
Transoesophageal echocardiogram (TOE)
If S. aureus bacteraemia or suspected endocarditis; refer to cardiology
Specialist
Venography / fistulogram
If stenosis suspected on ultrasound or access dysfunction not explained by clinical exam

Dialysis Water Quality Testing

  • Bacterial culture and endotoxin assay: quarterly (monthly for HDF).
  • Chemical analysis (aluminium, chloramine, fluoride): per AS/NZS 4753 โ€” typically annually or after system changes.
  • Performed by NATA-accredited laboratories; results documented in unit quality records.

Special Populations

๐Ÿคฐ Pregnancy
HD prescription: Increase to 5โ€“6 sessions/week, 4+ hours each (target Kt/V โ‰ฅ1.7 per session); intensify to manage fluid and solute load of pregnancy.
Foetal monitoring: High-risk obstetric care; foetal growth scans Q2 weeks from 28 weeks; cardiotocography (CTG) from 34 weeks.
EPO: Dose may need to increase by 50โ€“100%; target Hb 100โ€“110 g/L.
BP: Target <135/85 mmHg; labetalol, nifedipine (long-acting) preferred; avoid ACEi/ARBs.
Delivery: Planned at tertiary centre with NICU; vaginal delivery preferred unless obstetric contraindication.
๐Ÿ‘ถ Paediatrics
Access: CVC often required in young children (<20 kg); AVF creation by specialist paediatric vascular surgeon when feasible.
Dialyser: Use small-surface-area dialysers (e.g., 0.2โ€“0.4 mยฒ for infants); blood volume of extracorporeal circuit must not exceed 10% of patient blood volume.
Adequacy: Targets based on body surface area; paediatric nephrologist should direct prescription.
Growth: Monitor height velocity; recombinant growth hormone (somatropin) โ€” PBS Authority Required for CKD growth failure.
Psychosocial: School reintegration; child life specialist input; family-centred care model.
๐Ÿ‘ด Elderly (โ‰ฅ75 years)
Goals of care: Shared decision-making re: dialysis vs. conservative care; consider frailty, cognitive function, and patient preferences.
IDH risk: Higher due to impaired baroreceptor sensitivity; use cool dialysate, midodrine, and lower UF rates.
Access: AVF may have higher failure rates; AVG may be more appropriate; CVC may be acceptable if limited life expectancy.
Comorbidities: Higher burden of CVD, dementia, falls; medication reconciliation critical.
Conservative management: RACP Position Statement supports conservative care pathway when dialysis unlikely to extend meaningful survival; ensure advance care plan documented.
๐Ÿฉธ Residual Renal Function
Preserve RRF: Avoid nephrotoxins (NSAIDs, IV contrast, aminoglycosides); ACEi/ARB may be continued if tolerated.
Benefits: Better volume control, improved Kt/V, reduced mortality.
Monitoring: 24-hour urine volume and creatinine clearance Q3โ€“6 months to track RRF decline.
๐Ÿซ Hepatic Impairment
Medication adjustments: Heparin metabolised hepatically โ€” no dose change for UFH, but monitor closely; reduce doses of hepatically cleared drugs.
Ascites: Large-volume paracentesis pre-HD may improve tolerance; avoid concurrent UF if haemodynamically unstable.
Hepatorenal syndrome: HD provides temporary bridge; liver transplant assessment if candidate.
๐Ÿ›ก๏ธ Immunocompromised
Infection risk: Higher incidence of access-related and systemic infections; lower threshold for blood cultures.
Vaccination: Ensure complete vaccination schedule including hepatitis B, influenza, pneumococcal, COVID-19; live vaccines contraindicated in transplant candidates.
Transplant referral: Early discussion of transplantation as preferred long-term RRT if suitable candidate.

Aboriginal and Torres Strait Islander Health Considerations

Aboriginal and Torres Strait Islander Health
Epidemiology
Aboriginal and Torres Strait Islander peoples are 4โ€“8 times more likely to commence dialysis than non-Indigenous Australians. ESKD incidence peaks at ages 45โ€“64 years (10โ€“15 years younger than non-Indigenous patients). Diabetes is the primary cause in >70% of cases (ANZDATA 2023).
Remote access
Many patients from remote communities must relocate to regional or metropolitan centres for HD. State/territory Patient Assisted Travel Schemes (PATS) provide financial support. Satellite dialysis units in Alice Springs, Katherine, Cairns, and Broome reduce relocation burden but capacity remains limited.
Home HD programmes
Home HD is actively promoted for Indigenous patients where housing, water supply, and electricity infrastructure permit. Community-based training programmes and renal nurse outreach services (e.g., Purple House โ€” Western Desert Nganampa Walytja Palyantjaku Tjutaku Aboriginal Corporation) support home HD in remote Central Australia.
Cultural safety
Incorporate Aboriginal Health Workers and Liaison Officers (AHWLOs) into the HD care team. Respect Sorry Business, kinship obligations, and ceremonial leave. Provide culturally safe patient education materials (Kidney Health Australia Aboriginal resources). Gender-sensitive care: consider same-sex nursing staff where requested.
Social determinants
Address overcrowded housing (affects infection risk and home HD feasibility), food security (phosphate and potassium dietary restrictions may be impractical), transport (regular HD attendance), and health literacy. Link with Aboriginal Community Controlled Health Organisations (ACCHOs) and social workers.
Infection
Higher rates of hepatitis B and C in some communities โ€” universal HBV vaccination at ESKD registration; dedicated HD machines for HBsAg-positive patients per jurisdiction policy. Higher rates of rheumatic heart disease โ€” consider this in patients with CVCs and valvular disease (TOE for S. aureus bacteraemia).
Outcome disparities
Despite higher incidence, transplant rates for Indigenous patients are significantly lower than non-Indigenous patients. Barriers include remoteness, comorbidity burden, and cultural factors. Active engagement with transplant services, pre-emptive waitlisting, and advocacy are essential.
Key resources
RHDAustralia (rhdaustralia.org.au) โ€” rheumatic heart disease guidelines; NACCHO โ€” primary care coordination; Kidney Health Australia โ€” Indigenous renal resources; AIHW โ€” CKD and Indigenous health reports.

Quick Reference โ€” HD Prescription Summary

Standard in-centre HD
4 hours ร— 3/week; QB 300โ€“400 mL/min; QD 500 mL/min; high-flux dialyser
Lifelong or until transplant
spKt/V โ‰ฅ1.4; URR โ‰ฅ70%
Home haemodialysis
4โ€“5 hours ร— 4โ€“5/week or nocturnal 6โ€“8 hrs ร— 5โ€“6/week; self-cannulation
Patient-directed schedule
Equivalent or superior outcomes; patient training 6โ€“12 weeks
Acute HD (new starter)
2โ€“3 hours first session; QB 150โ€“200 mL/min; build to standard over 1โ€“2 weeks
Transition to maintenance schedule
Monitor for disequilibrium syndrome; consider hypertonic saline
Emergency HD (hyperkalaemia)
Calcium gluconate 10% 20 mL IV first; then HD 2โ€“3 hrs; QD 500 mL/min; K-free dialysate
Single session + ongoing as needed
ECG monitoring throughout; serial Kโบ levels; calcium resonium as adjunct

๐Ÿ“š References

  1. 1. Australia and New Zealand Dialysis and Transplant Registry (ANZDATA). ANZDATA 45th Annual Report 2022. Adelaide: SA Health and Medical Research Institute; 2023.
  2. 2. Kidney Disease Outcomes Quality Initiative (KDOQI). KDOQI Clinical Practice Guideline for Hemodialysis Adequacy: 2015 Update. Am J Kidney Dis. 2015;66(5):884-930.
  3. 3. Caring for Australasians on Renal Impairment (CARI). CARI Guidelines: Haemodialysis Adequacy. 2012. Available at: www.cari.org.au.
  4. 4. Kidney Disease: Improving Global Outcomes (KDIGO) CKD-MBD Update Work Group. KDIGO 2017 Clinical Practice Guideline Update for the Diagnosis, Evaluation, Prevention, and Treatment of CKD-MBD. Kidney Int Suppl. 2017;7(1):1-59.
  5. 5. Maduell F, Moreso F, Pons M, et al. High-efficiency postdilution online hemodiafiltration reduces all-cause mortality in hemodialysis patients. J Am Soc Nephrol. 2013;24(3):487-497 (ESHOL trial).
  6. 6. Grooteman MPC, van den Dorpel MA, Bots ML, et al. Effect of online hemodiafiltration on all-cause mortality and cardiovascular outcomes. J Am Soc Nephrol. 2012;23(6):1087-1096 (CONTRAST trial).
  7. 7. Lok CE, Huber TS, Lee T, et al. KDOQI Clinical Practice Update on Vascular Access: 2019 Update. Am J Kidney Dis. 2020;75(4):487-510.
  8. 8. Mokrzycki MH, Lok CE. Traditional and non-traditional strategies to optimize catheter function: go with more flow. Kidney Int. 2010;78(12):1218-1231.
  9. 9. Daugirdas JT. Second generation logarithmic estimates of single-pool variable volume Kt/V: an analysis of error. J Am Soc Nephrol. 1993;4(5):1205-1213.
  10. 10. Australian Commission on Safety and Quality in Health Care (ACSQHC). National Safety and Quality Health Service Standards. 2nd ed. Sydney: ACSQHC; 2021.
  11. 11. Standards Australia. AS/NZS 4753: Water quality for haemodialysis and related applications. 2013.
  12. 12. Australian Institute of Health and Welfare (AIHW). Chronic kidney disease in Aboriginal and Torres Strait Islander people. Cat. no. PHE 254. Canberra: AIHW; 2023.
  13. 13. Hughes JT, Dembski L, Kerrigan V, et al. Gathering perspectives โ€” Aboriginal and Torres Strait Islander perspectives on kidney care. Nephrology. 2020;25(8):623-631.
  14. 14. Royal Australasian College of Physicians (RACP). Adult Active Refusal of Life-Prolonging Medical Treatment โ€” Position Statement. Sydney: RACP; 2018.
  15. 15. Purple House (Western Desert Nganampa Walytja Palyantjaku Tjutaku Aboriginal Corporation). Community-based dialysis and renal support services. Available at: www.purplehouse.org.au.